Semaglutide

Semaglutide has a blood half-life of about 7 days, making it suitable for weekly injections.

Weeks 1–4 — 0.25 mg

Weeks 5–8 — 0.5 mg

Weeks 9–12 — 1 mg

From week 13 — 1–2 mg if needed

Injection site: Inject into your abdomen, thigh or upper arm

Semaglutide is a GLP-1 receptor agonist, meaning that it mimics the action of the human incretin glucagon-like peptide-1 (GLP-1), thereby increasing insulin secretion and increasing blood sugar disposal and improving glycemic control.

It is used as an antidiabetic medication used for the treatment of type 2 diabetes and long-term weight management.

It reduces food intake by lowering appetite and slowing down digestion in the stomach, helping to reduce body fat.

Short term - Lyophilized peptides will remain stable at room temperature for 30-60 days. However, upon receipt all peptides should be stored in the refrigerator (under 4C (39F) for maximum stability and longevity. Peptides stored at this temperature can last 1-2 years.

Long term - If you are not going to use the peptides withing 1-2 months it is preferable to store the peptides in a freezer at -18C (0F). Peptides stored at this temperature can last 2-3 years. Even more preferable for long term storage is freezing at -80C (-112F) in order to preserve the peptides stability long term.

Short term - Peptide solutions generally remain stable up to 30 days when stored in the refrigerator at 4C (39F) depending on the length of the peptide sequence and its inherent instability factors.

Long term - If peptides absolutely must be stored in solution, sterile buffers at pH 5-6 should be used if possible, and the peptide solution should be separated into aliquots to avoid repeated freezing and thawing. Freezing at -80C (-112F) is optimal in order to preserve the peptides stability.

• Protein intake: 1.6–2.2 g per kg of body weight

• Regular strength training

• Electrolyte monitoring

• Monitor total calorie intake

• Fiber: 25–40 g per day

• Adequate water intake

• Avoid large high-fat meals, as they may increase nausea

• Electrolytes

• Magnesium

• Omega-3

• Vitamin D

Semaglutide reduces high blood sugar by increasing the amount of insulin released, decreasing the amount of glucagon released, and delaying gastric emptying. Semaglutide also controls appetite and helps reduce the amount of food a person wants to eat. In addition, Semaglutide reduces preference for high-fat meals.

In clinical studies, Semaglutide had a positive effect on plasma lipids, reduced systolic blood pressure and reduced inflammation. In animal studies, Semaglutide slowed the development of atherosclerosis by preventing the progression of aortic plaque development and reducing plaque inflammation.

Tell your doctor if you have signs of a thyroid tumor, such as swelling or a lump in your neck, trouble swallowing, hoarseness, or shortness of breath.

You should not use Semaglutide if you have multiple endocrine neoplasia type 2 (tumors in the glands) or a personal or family history of medullary thyroid cancer.

Ask your doctor about taking Semaglutide if you have ever had the following diseases or conditions:diabetic ketoacidosispancreatitis;kidney diseaseeye problems caused by diabetes (retinopathy).